Dark Matter Search Results from <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"> <mml:mrow> <mml:mn>4.2</mml:mn> <mml:mtext> </mml:mtext> <mml:mtext> </mml:mtext> <mml:mtext>Tonne</mml:mtext> <mml:mtext>−</mml:mtext> <mml:mtext>Years</mml:mtext> </mml:mrow> </mml:math> of Exposure of the LUX-ZEPLIN (LZ) Experiment

We report results of a search for nuclear recoils induced by weakly interacting massive particle (WIMP) dark matter using the LUX-ZEPLIN (LZ) two-phase xenon time projection chamber. This analysis uses a total exposure of 4.2 ± 0.1 tonne-years from 280 live days of LZ operation, of which 3.3 ± 0.1 tonne-years and 220 live days are new. A technique to actively tag background electronic recoils from Pb 214 β decays is featured for the first time. Enhanced electron-ion recombination is observed in two-neutrino double electron capture decays of Xe 124 , representing a noteworthy new background. After removal of artificial signal-like events injected into the dataset to mitigate analyzer bias, we find no evidence for an excess over expected backgrounds. World-leading constraints are placed on spin-independent (SI) and spin-dependent WIMP-nucleon cross sections for masses ≥ 9     GeV / c 2 . The strongest SI exclusion set is 2.2 × 10 − 48     cm 2 at the 90% confidence level and the best SI median sensitivity achieved is 5.1 × 10 − 48     cm 2 , both for a mass of 40     GeV / c 2 .