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Conformational landscape and ligand-dependent clustering of the human type 2 IP3 receptor

Keyword: Intracellular

Publisher: Nature.com

Published: Jun 19, 2026

Inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs) are tetrameric ER Ca2+ channels that shape intracellular Ca2+ signaling in response to IP3, regulating diverse physiological processes. The struct… [+1022 chars]

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