Research Radar

Academic Publication • Published Jan 8, 2025

Myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment and their targeting in cancer therapy

152

Academic Publication • Published Jan 7, 2025

World Medical Association Declaration of Helsinki

This JAMA Special Communication presents the 2024 revision of the World Medical Association’s Declaration of Helsinki, a set of principles to guide the ethical treatment of participants in medical research.

890

Academic Publication • Published Jan 7, 2025

The role of light in regulating plant growth, development and sugar metabolism: a review

Light provides the necessary energy for plant photosynthesis, which allows plants to produce organic matter and energy conversion, during plant growth and development. Light provides material energy to plants as the basis for cell division and dif...

116

KEGG: biological systems database as a model of the real world

Abstract KEGG (https://www.kegg.jp/) is a database resource for representation and analysis of biological systems. Pathway maps are the primary dataset in KEGG representing systemic functions of the cell and the organism in terms of...

2,055

VFDB 2025: an integrated resource for exploring anti-virulence compounds

Abstract With the escalating crisis of bacterial multidrug resistance, anti-virulence therapeutic strategies have emerged as a highly promising alternative to conventional antibiotic treatments. Anti-virulence compounds are specific...

151

CZ CELLxGENE Discover: a single-cell data platform for scalable exploration, analysis and modeling of aggregated data

Abstract Hundreds of millions of single cells have been analyzed using high-throughput transcriptomic methods. The cumulative knowledge within these datasets provides an exciting opportunity for unlocking insights into health and di...

288

The STRING database in 2025: protein networks with directionality of regulation

Abstract Proteins cooperate, regulate and bind each other to achieve their functions. Understanding the complex network of their interactions is essential for a systems-level description of cellular processes. The STRING database co...

496

Updated resources for exploring experimentally-determined PDB structures and Computed Structure Models at the RCSB Protein Data Bank

Abstract The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB, RCSB.org), the US Worldwide Protein Data Bank (wwPDB, wwPDB.org) data center for the global PDB archive, provides access to the PDB data ...

244

InterPro: the protein sequence classification resource in 2025

Abstract InterPro (https://www.ebi.ac.uk/interpro) is a freely accessible resource for the classification of protein sequences into families. It integrates predictive models, known as signatures, from multiple member databases to cl...

831

miRTarBase 2025: updates to the collection of experimentally validated microRNA–target interactions

Abstract MicroRNAs (miRNAs) are small non-coding RNAs (18–26 nucleotides) that regulate gene expression by interacting with target mRNAs, affecting various physiological and pathological processes. miRTarBase, a database of experime...

179

The NHGRI-EBI GWAS Catalog: standards for reusability, sustainability and diversity

Abstract The NHGRI-EBI GWAS Catalog serves as a vital resource for the genetic research community, providing access to the most comprehensive database of human GWAS results. Currently, it contains close to 7 000 publications for ...

338

UniProt: the Universal Protein Knowledgebase in 2025

Abstract The aim of the UniProt Knowledgebase (UniProtKB; https://www.uniprot.org/) is to provide users with a comprehensive, high-quality and freely accessible set of protein sequences annotated with functional information. In this...

1,723

Generic Diagramming Platform (GDP): a comprehensive database of high-quality biomedical graphics

Abstract High-quality schematic illustrations are fundamental to the publication of scientific achievements in biomedical research, which are crucial for effectively conveying complex biomedical concepts. However, creating such illu...

1,032

The UCSC Genome Browser database: 2025 update

Abstract The UCSC Genome Browser (https://genome.ucsc.edu) is a widely utilized web-based tool for visualization and analysis of genomic data, encompassing over 4000 assemblies from diverse organisms. Since its release in 2001, it h...

551

Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2025

Abstract The National Genomics Data Center (NGDC), which is a part of the China National Center for Bioinformation (CNCB), offers a comprehensive suite of database resources to support the global scientific community. Amidst the ...

266

OrthoDB and BUSCO update: annotation of orthologs with wider sampling of genomes

Abstract OrthoDB (https://www.orthodb.org) offers evolutionary and functional annotations of orthologous genes in the widest sampling of eukaryotes, prokaryotes, and viruses, extending experimental gene function knowledge to newly s...

220

The Pfam protein families database: embracing AI/ML

Abstract The Pfam protein families database is a comprehensive collection of protein domains and families used for genome annotation and protein structure and function analysis (https://www.ebi.ac.uk/interpro/). This update describe...

250

Artificial lemming algorithm: a novel bionic meta-heuristic technique for solving real-world engineering optimization problems

240

Academic Publication • Published Jan 3, 2025

AI Tools in Society: Impacts on Cognitive Offloading and the Future of Critical Thinking

The proliferation of artificial intelligence (AI) tools has transformed numerous aspects of daily life, yet its impact on critical thinking remains underexplored. This study investigates the relationship between AI tool usage and critical thinking...

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