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Metabolic dysfunction-associated steatotic liver disease: heterogeneous pathomechanisms and effectiveness of metabolism-based treatment

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February 1, 2025
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Metabolic dysfunction-associated steatotic liver disease: heterogeneous pathomechanisms and effectiveness of metabolism-based treatment

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The SIRT3-DsbA-L-TFAM axis restrains cGAS-driven metabolic dysfunction-associated steatohepatitis in male mice

This study identifies a mitochondrial protection pathway that safeguards mitochondrial DNA integrity and limits liver damage. Disrupting this pathway triggers inflammation and fibrosis, while resto...

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Liver diseases: epidemiology, causes, trends and predictions

Abstract As a highly complex organ with digestive, endocrine, and immune-regulatory functions, the liver is pivotal in maintaining physiological homeostasis through its roles in metabolis...

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Global Cases of Metabolic Liver Disease Surge 143% Since 1990, Study Finds

Overview A new global analysis published in The Lancet Gastroenterology & Hepatology reports that cases of metabolic dysfunction-associated steatotic liver disease (MASLD) have surged 143% since 19...

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EASL–EASD–EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD)

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Yes, highly correlated activity was mapped. An entry titled 'The SIRT3-DsbA-L-TFAM axis restrains cGAS-driven metabolic dysfunction-associated steatohepatitis in male mice' discusses this: This study identifies a mitochondrial protection pathway that safeguards mitochondrial DNA integrity and limits liver damage. Disrupting this pathw...

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