Rapid and Highly Selective Dopamine Sensing with CuInSe2-Modified Nanocomposite

As an important neurotransmitter, the concentration of dopamine (DA) reflects certain physiological conditions and DA-related diseases. Rapid monitoring of DA levels is of great significance in regulating body health. However, regular electrochemical DA sensors suffer from poor sensitivity, low selectivity and interference immunity, as well as a complex preparation process. Herein, we developed an accessible and cost-effective electrochemical sensor with a copper indium selenide (CuInSe2 or CIS)-modified screen-printed carbon electrode for DA discrimination. This DA sensor was developed using a facile one-step hydrothermal method without high-temperature quenching. Benefitting from the inherent merits of CIS and the conversion of Cu2+ and Cu+ during the catalytic reaction, the sensor attained both excellent sensitivity (2.511 μA·µM−1·cm−1) and selectivity among multiple substances interfering with DA. This work demonstrates the potential to improve the analytical performance of traditional electrochemical sensors.