Research Radar

Academic Publication • Published Jan 10, 2025

Mitochondrial diseases: from molecular mechanisms to therapeutic advances

AbstractMitochondria are essential for cellular function and viability, serving as central hubs of metabolism and signaling. They possess various metabolic and quality control mechanisms crucial for maintaining normal cellular activities. Mitochon...

Academic Publication • Published Jan 10, 2025

The Role of Polyphenols in Abiotic Stress Tolerance and Their Antioxidant Properties to Scavenge Reactive Oxygen Species and Free Radicals

Plants have evolved complex mechanisms to cope with diverse abiotic stresses, with the phenylpropanoid pathway playing a central role in stress adaptation. This pathway produces an array of secondary metabolites, particularly polyphenols, which se...

Academic Publication • Published Jan 9, 2025

Tumor metabolic regulators: key drivers of metabolic reprogramming and the promising targets in cancer therapy

Academic Publication • Published Jan 9, 2025

Short-chain fatty acid metabolites propionate and butyrate are unique epigenetic regulatory elements linking diet, metabolism and gene expression

Abstract The short-chain fatty acids (SCFAs) propionate and butyrate have beneficial health effects, are produced in large amounts by microbial metabolism and have been identified as unique acyl lysine histone marks. To better un...

Academic Publication • Published Jan 9, 2025

Accurate predictions on small data with a tabular foundation model

AbstractTabular data, spreadsheets organized in rows and columns, are ubiquitous across scientific fields, from biomedicine to particle physics to economics and climate science1,2. The fundamental prediction task of filling in missing values of a ...

Academic Publication • Published Jan 8, 2025

Myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment and their targeting in cancer therapy

Academic Publication • Published Jan 8, 2025

The Crack Propagation Behaviour of CO2 Fracturing Fluid in Unconventional Low Permeability Reservoirs: Factor Analysis and Mechanism Revelation

To circumvent the numerous deficiencies inherent to water-based fracturing fluids and the associated greenhouse effect, CO2 fracturing fluids are employed as a novel reservoir working fluid for reservoir reconstruction in unconventional oil fields...

Academic Publication • Published Jan 8, 2025

Enhancing photocatalytic hydrogen peroxide generation by tuning hydrazone linkage density in covalent organic frameworks

Academic Publication • Published Jan 8, 2025

Fluid-Actuated Nano–Micro–Macro Structure Morphing Enables Smart Multispectrum Compatible Stealth

Academic Publication • Published Jan 7, 2025

World Medical Association Declaration of Helsinki

This JAMA Special Communication presents the 2024 revision of the World Medical Association’s Declaration of Helsinki, a set of principles to guide the ethical treatment of participants in medical research.

Academic Publication • Published Jan 7, 2025

The role of light in regulating plant growth, development and sugar metabolism: a review

Light provides the necessary energy for plant photosynthesis, which allows plants to produce organic matter and energy conversion, during plant growth and development. Light provides material energy to plants as the basis for cell division and dif...

Academic Publication • Published Jan 6, 2025

InterPro: the protein sequence classification resource in 2025

Abstract InterPro (https://www.ebi.ac.uk/interpro) is a freely accessible resource for the classification of protein sequences into families. It integrates predictive models, known as signatures, from multiple member databases to cl...

Academic Publication • Published Jan 6, 2025

UniProt: the Universal Protein Knowledgebase in 2025

Abstract The aim of the UniProt Knowledgebase (UniProtKB; https://www.uniprot.org/) is to provide users with a comprehensive, high-quality and freely accessible set of protein sequences annotated with functional information. In this...

Academic Publication • Published Jan 6, 2025

OrthoDB and BUSCO update: annotation of orthologs with wider sampling of genomes

Abstract OrthoDB (https://www.orthodb.org) offers evolutionary and functional annotations of orthologous genes in the widest sampling of eukaryotes, prokaryotes, and viruses, extending experimental gene function knowledge to newly s...

Academic Publication • Published Jan 6, 2025

The Pfam protein families database: embracing AI/ML

Abstract The Pfam protein families database is a comprehensive collection of protein domains and families used for genome annotation and protein structure and function analysis (https://www.ebi.ac.uk/interpro/). This update describe...

Academic Publication • Published Jan 6, 2025

Updated resources for exploring experimentally-determined PDB structures and Computed Structure Models at the RCSB Protein Data Bank

Abstract The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB, RCSB.org), the US Worldwide Protein Data Bank (wwPDB, wwPDB.org) data center for the global PDB archive, provides access to the PDB data ...

Academic Publication • Published Jan 6, 2025

Artificial lemming algorithm: a novel bionic meta-heuristic technique for solving real-world engineering optimization problems

Academic Publication • Published Jan 6, 2025

GENCODE 2025: reference gene annotation for human and mouse

Abstract GENCODE produces comprehensive reference gene annotation for human and mouse. Entering its twentieth year, the project remains highly active as new technologies and methodologies allow us to catalog the genome at ever-incre...

Academic Publication • Published Jan 6, 2025

The NHGRI-EBI GWAS Catalog: standards for reusability, sustainability and diversity

Abstract The NHGRI-EBI GWAS Catalog serves as a vital resource for the genetic research community, providing access to the most comprehensive database of human GWAS results. Currently, it contains close to 7 000 publications for ...

Academic Publication • Published Jan 6, 2025

miRTarBase 2025: updates to the collection of experimentally validated microRNA–target interactions

Abstract MicroRNAs (miRNAs) are small non-coding RNAs (18–26 nucleotides) that regulate gene expression by interacting with target mRNAs, affecting various physiological and pathological processes. miRTarBase, a database of experime...