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Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and disease

296
Citations
July 10, 2024
Published Date

Research Abstract & Technology Focus

AbstractWnts are secreted, lipid-modified proteins that bind to different receptors on the cell surface to activate canonical or non-canonical Wnt signaling pathways, which control various biological processes throughout embryonic development and adult life. Aberrant Wnt signaling pathway underlies a wide range of human disease pathogeneses. In this review, we provide an update of Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and diseases. The Wnt proteins, receptors, activators, inhibitors, and the crosstalk of Wnt signaling pathways with other signaling pathways are summarized and discussed. We mainly review Wnt signaling functions in bone formation, homeostasis, and related diseases, and summarize mouse models carrying genetic modifications of Wnt signaling components. Moreover, the therapeutic strategies for treating bone diseases by targeting Wnt signaling, including the extracellular molecules, cytosol components, and nuclear components of Wnt signaling are reviewed. In summary, this paper reviews our current understanding of the mechanisms by which Wnt signaling regulates bone formation, homeostasis, and the efforts targeting Wnt signaling for treating bone diseases. Finally, the paper evaluates the important questions in Wnt signaling to be further explored based on the progress of new biological analytical technologies.
-catenin signaling components mechanisms formation homeostasis
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This literature focuses on: AbstractWnts are secreted, lipid-modified proteins that bind to different receptors on the cell surface to activate canonical or non-canonical Wnt signaling pathways, which control various biological processes throughout embryonic development and ...

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Yes, highly correlated activity was mapped. An entry titled 'Targeting the Ip6k2–Runx2 axis disrupts osteoblast–osteoclast coupling to treat osteoporosis' discusses this: The study shows that Ip6k2 partners with Runx2 to drive osteoclast activity. Targeting Ip6k2 selectively reduces bone resorption, increases bone ma...

What other academic literature is closely related to 'Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and disease'?

Yes, highly correlated activity was mapped. An entry titled 'Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects' discusses this: AbstractIron, an essential mineral in the body, is involved in numerous physiological processes, making the maintenance of iron homeostasis crucial...

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