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In-cell architecture of the mitochondrial respiratory chain

78
Citations
March 21, 2025
Published Date

Research Abstract & Technology Focus

Mitochondria regenerate adenosine triphosphate (ATP) through oxidative phosphorylation. This process is carried out by five membrane-bound complexes collectively known as the respiratory chain, working in concert to transfer electrons and pump protons. The precise organization of these complexes in native cells is debated. We used in situ cryo–electron tomography to visualize the native structures and organization of several major mitochondrial complexes in
Chlamydomonas reinhardtii
cells. ATP synthases and respiratory complexes segregate into curved and flat crista membrane domains, respectively. Respiratory complexes I, III, and IV assemble into a respirasome supercomplex, from which we determined a native 5-angstrom (Å) resolution structure showing binding of electron carrier cytochrome
c
. Combined with single-particle cryo–electron microscopy at 2.4-Å resolution, we model how the respiratory complexes organize inside native mitochondria.
in-cell architecture mitochondrial respiratory chain
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What is the core focus of the research titled 'In-cell architecture of the mitochondrial respiratory chain'?

This literature focuses on: Mitochondria regenerate adenosine triphosphate (ATP) through oxidative phosphorylation. This process is carried out by five membrane-bound complexes collectively known as the respiratory chain, working in concert to transfer electrons and pump pro...

Are there open-source GitHub repositories related to In-cell architecture of the mitochondrial respiratory chain?

Yes, open-source projects like kyegomez/OpenMythos (A theoretical reconstruction of the Claude Mythos architecture, built from first principles using the available research literature.) are actively building upon these concepts.

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Yes, highly correlated activity was mapped. An entry titled 'In-cell architecture of the mitochondrial respiratory chain' discusses this: Mitochondria regenerate adenosine triphosphate (ATP) through oxidative phosphorylation. This process is carried out by five membrane-bound complexe...

Are there commercial applications of 'In-cell architecture of the mitochondrial respiratory chain' in market news publications?

Yes, highly correlated activity was mapped. An entry titled 'Mitochondria directly interact with the nuclear pore complex' discusses this: Mitochondria interact directly with the nuclear pore complex via VDAC1–RANBP2 binding to sustain nuclear ATP levels.

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