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Mechanism of antibacterial resistance, strategies and next-generation antimicrobials to contain antimicrobial resistance: a review

144
Citations
August 16, 2024
Published Date

Research Abstract & Technology Focus

Antibacterial drug resistance poses a significant challenge to modern healthcare systems, threatening our ability to effectively treat bacterial infections. This review aims to provide a comprehensive overview of the types and mechanisms of antibacterial drug resistance. To achieve this aim, a thorough literature search was conducted to identify key studies and reviews on antibacterial resistance mechanisms, strategies and next-generation antimicrobials to contain antimicrobial resistance. In this review, types of resistance and major mechanisms of antibacterial resistance with examples including target site modifications, decreased influx, increased efflux pumps, and enzymatic inactivation of antibacterials has been discussed. Moreover, biofilm formation, and horizontal gene transfer methods has also been included. Furthermore, measures (interventions) taken to control antimicrobial resistance and next-generation antimicrobials have been discussed in detail. Overall, this review provides valuable insights into the diverse mechanisms employed by bacteria to resist the effects of antibacterial drugs, with the aim of informing future research and guiding antimicrobial stewardship efforts.
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What is the core focus of the research titled 'Mechanism of antibacterial resistance, strategies and next-generation antimicrobials to contain antimicrobial resistance: a review'?

This literature focuses on: Antibacterial drug resistance poses a significant challenge to modern healthcare systems, threatening our ability to effectively treat bacterial infections. This review aims to provide a comprehensive overview of the types and mechanisms of antiba...

What other academic literature is closely related to 'Mechanism of antibacterial resistance, strategies and next-generation antimicrobials to contain antimicrobial resistance: a review'?

Yes, highly correlated activity was mapped. An entry titled 'VFDB 2025: an integrated resource for exploring anti-virulence compounds' discusses this: Abstract With the escalating crisis of bacterial multidrug resistance, anti-virulence therapeutic strategies have emerged as a highl...

Are there commercial applications of 'Mechanism of antibacterial resistance, strategies and next-generation antimicrobials to contain antimicrobial resistance: a review' in market news publications?

Yes, highly correlated activity was mapped. An entry titled 'Genomic convergence of multidrug resistance, virulence-associated loci, and phage defense systems in Klebsiella pneumoniae from pharmaceutical wastewater in Bangladesh' discusses this: Scientific Reports - Genomic convergence of multidrug resistance, virulence-associated loci, and phage defense systems in Klebsiella pneumoniae fro...

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