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The Role of Inflammation in Cancer: Mechanisms of Tumor Initiation, Progression, and Metastasis

280
Citations
March 25, 2025
Published Date

Research Abstract & Technology Focus

Inflammation is an essential component of the immune response that protects the host against pathogens and facilitates tissue repair. Chronic inflammation is a critical factor in cancer development and progression. It affects every stage of tumor development, from initiation and promotion to invasion and metastasis. Tumors often create an inflammatory microenvironment that induces angiogenesis, immune suppression, and malignant growth. Immune cells within the tumor microenvironment interact actively with cancer cells, which drives progression through complex molecular mechanisms. Chronic inflammation is triggered by factors such as infections, obesity, and environmental toxins and is strongly linked to increased cancer risk. However, acute inflammatory responses can sometimes boost antitumor immunity; thus, inflammation presents both challenges and opportunities for therapeutic intervention. This review examines how inflammation contributes to tumor biology, emphasizing its dual role as a critical factor in tumorigenesis and as a potential therapeutic target.
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What is the core focus of the research titled 'The Role of Inflammation in Cancer: Mechanisms of Tumor Initiation, Progression, and Metastasis'?

This literature focuses on: Inflammation is an essential component of the immune response that protects the host against pathogens and facilitates tissue repair. Chronic inflammation is a critical factor in cancer development and progression. It affects every stage of tumor ...

What other academic literature is closely related to 'The Role of Inflammation in Cancer: Mechanisms of Tumor Initiation, Progression, and Metastasis'?

Yes, highly correlated activity was mapped. An entry titled 'The Role of Inflammation in Cancer: Mechanisms of Tumor Initiation, Progression, and Metastasis' discusses this: Inflammation is an essential component of the immune response that protects the host against pathogens and facilitates tissue repair. Chronic infla...

Are there commercial applications of 'The Role of Inflammation in Cancer: Mechanisms of Tumor Initiation, Progression, and Metastasis' in market news publications?

Yes, highly correlated activity was mapped. An entry titled 'Pregnancy promotes tumor metastasis through adenosine-induced immunosuppressive neutrophils in pre-metastatic microenvironment' discusses this: Accelerated cancer progression during pregnancy has been previously reported. Here the authors show that adenosine produced in the uterus of pregna...

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