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Mechano-electrical coupling in cell volume regulation: physical mechanisms, physiological functions, and challenges

Dingnan Wu, Weijian Wang, Xiaosong Guo, Ruowen Tang, Yuehua Yang, Hongyuan Jiang
October 5, 2026
Published Date

Research Abstract & Technology Focus

Cellular volume homeostasis is essential for maintaining the stability of cell structure and functions. The regulation of cell volume is a mechano-electrical coupling process, where mechanical forces (such as osmotic pressure, hydrostatic pressure, myosin contraction, and membrane tension) and electrical signals (including ion fluxes and membrane potential) are intricately coupled. In this review, we explore the physical mechanisms underlying this coupling, its critical physiological roles, and the current challenges in the field. We discuss key elements like mechanosensitive ion channels, cytoskeletal dynamics, membrane tension, and membrane potential. By summarizing existing knowledge and pointing out open questions, this review offers an integrated perspective on how cells sense and integrate mechanical and electrical cues during volume regulation, and suggests important directions for future research.
Coupling (piping) Physics Materials science Volume (thermodynamics) Chemistry Work (physics)
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What is the core focus of the research titled 'Mechano-electrical coupling in cell volume regulation: physical mechanisms, physiological functions, and challenges'?

This literature focuses on: Cellular volume homeostasis is essential for maintaining the stability of cell structure and functions. The regulation of cell volume is a mechano-electrical coupling process, where mechanical forces (such as osmotic pressure, hydrostatic pressure...

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What other academic literature is closely related to 'Mechano-electrical coupling in cell volume regulation: physical mechanisms, physiological functions, and challenges'?

Yes, highly correlated activity was mapped. An entry titled 'Advanced Mechano‐Electrical Coupling Biomaterials for Orthopedics: From Fundamental Mechanisms to Clinical Translation' discusses this: Musculoskeletal tissues are continuously subjected to mechanical stimulation during physiological activity, accompanied by the generation of endoge...

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